Gènes homologues de l'ecdysone  sur blast 2.

41 2
SWALL:Q90968 Q90968 RETINOIC ACID RECEPTOR GAMMA 2 IS... 264 2.0e-41 2
SWALL:O97716 O97716 THYROID HORMONE RECEPTOR ALPHA 2. 282 2.1e-41 2
SWALL:Q90271 Q90271 RETINOIC ACID RECEPTOR ALPHA-2.A. 259 3.0e-41 2
SWALL:Q9QUS1 Q9QUS1 NUCLEAR RECEPTOR. 268 3.4e-41 2
SWALL:THAA_PAROL Q91241 THYROID HORMONE RECEPTOR ALPHA A ... 268 3.8e-41 2
SWALL:THAB_PAROL Q91242 THYROID HORMONE RECEPTOR ALPHA B ... 263 5.7e-41 2
SWALL:ERBA_AVIER P03373 ERBA ONCOGENE PROTEIN.

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FlyBase Report

Gene EcR

D. melanogaster gene Ecdysone receptor , abbreviated as EcR , is reported here . It encodes a product with the function ecdysteroid hormone receptor involved in carbohydrate metabolism which is localised to the nucleus; it is expressed in the prepupa and pupa (Malpighian tubule , dorsal metathoracic disc , embryonic/larval fat body , embryonic/larval midgut and 14 other listed tissues). It has a known homologue in Lucilia cuprina . It has been sequenced and its amino acid sequence contains a nuclear hormones receptors DNA-binding region signature . It has been mapped cytologically to 42A6--9 . It interacts genetically with Dfd , Pc and Sin3A . There are 48 recorded mutant alleles , of which at least 7 are available from the public stock centers. Loss-of-function mutations have been isolated which affect the germ-line clone egg chamber , the oocyte stage S14 and the follicle cell and are embryonic recessive lethal and recessive conditional ts female sterile. EcR is discussed in 168 published references , dated between 1988 and 1999. These include at least 23 studies of mutant phenotypes , 2 studies of wild-type function and 2 molecular studies . Among findings on EcR mutants, mutations in EcR reveal functional differences among the receptor isoforms encoded by the EcR gene. Among findings on EcR function, EcR function is required maternally for normal oogenesis.

LOCUS       DROECR       5534 bp    mRNA            INV       26-APR-1993
DEFINITION  Drosophila melanogaster ecdysone receptor (EcR) mRNA, complete cds.
ACCESSION   M74078
VERSION     M74078.1  GI:157317
KEYWORDS    ecdysone receptor; steroid receptor.
SOURCE      Drosophila melanogaster (strain Canton S) Instar, last larval mixed
            internal tissues cDNA to mRNA.
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Arthropoda; Tracheata; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
REFERENCE   1  (bases 1 to 5534)
  AUTHORS   Koelle,M.R., Talbot,W.S., Segraves,W.A., Bender,M.T., Cherbas,P.
            and Hogness,D.S.
  TITLE     The Drosophila EcR gene encodes an ecdysone receptor, a new member
            of the steroid receptor superfamily
  JOURNAL   Cell 67, 59-77 (1991)
  MEDLINE   92005697
FEATURES             Location/Qualifiers
     source          1..5534
                     /organism="Drosophila melanogaster"
                     /strain="Canton S"
                     /db_xref="taxon:7227"
                     /tissue_type="mixed internal tissues"
                     /dev_stage="Instar, last larval"
     gene            1..5534
                     /gene="EcR"
     exon            1..781
                     /gene="EcR"
                     /number=1
     exon            782..1747
                     /gene="EcR"
                     /number=2
     CDS             1069..3705
                     /gene="EcR"
                     /codon_start=1
                     /product="ecdysone receptor"
                     /protein_id="AAA28498.1"
                     /db_xref="GI:157318"
                     /translation="MKRRWSNNGGFMRLPEESSSEVTSSSNGLVLPSGVNMSPSSLDS
                     HDYCDQDLWLCGNESGSFGGSNGHGLSQQQQSVITLAMHGCSSTLPAQTTIIPINGNA
                     NGNGGSTNGQYVPGATNLGALANGMLNGGFNGMQQQIQNGHGLINSTTPSTPTTPLHL
                     QQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRS
                     DSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHY
                     NALTCEGCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECV
                     VPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPP
                     QHATIPLLPDEILAKCQARNIPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRIMSQPD
                     ENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRM
                     ARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMFSMKVDNVEYALLTA
                     IVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMSLVFYAKLLSILTELRTL
                     GNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHLQITQEENERLERAERMRAS
                     VGGAITAGIDCDSASTSAAAAAAQHQPQPQPQPQPSSLTQNDSQHQTQPQLQPQLPPQ
                     LQGQLQPQLQPQLQTQLQPQIQPQPQLLPVSAPVPASVTAPGSLSAVSTSSEYMGGSA
                     AIGPITPATTSSITAAVTASSTTSAVPMGNGVGVGVGVGGNVSMYANAQTAMALMGVA
                     LHSHQEQLIGGVAVKSEHSTTA"
     exon            1748..2262
                     /gene="EcR"
                     /number=3
     exon            2263..2406
                     /gene="EcR"
                     /number=4
     exon            2407..2559
                     /gene="EcR"
                     /number=5
     exon            2560..5534
                     /gene="EcR"
                     /number=5
     polyA_signal    4209..4214
                     /gene="EcR"
     polyA_signal    4819..4824
                     /gene="EcR"
     polyA_signal    5069..5074
                     /gene="EcR"
     polyA_signal    5180..5185
                     /gene="EcR"
BASE COUNT     1753 a   1295 c   1197 g   1289 t
ORIGIN      
        1 gaattcggca aaatacagca cacacaattg aaaacgacaa cctaacagta cggtttccca
       61 aagcacctta catttcaaaa ccgaaaaccc ccaaaatgtt gtaaccaaat aatgtttaaa
      121 tcacatatac acctacatat atttatgaaa aattgttaga caaatcccaa ataataccag
      181 ttcccccaac aaccgcaaca aacacaagtg caattcatcg gcaaaaatta atataaagtg
      241 caaatgcatt gtagctgaaa ctcaaacaat agtaaaaata catacataag tggtgaagaa
      301 gcaaaaggaa atagttctta aaataacgca aatcgagagc atatattcat atttgtacag
      361 atattatatg gcggctgcat agtgcaaact gcggctgagg gaatacagcg gtatcgaaat
      421 gtaaatagga aacaacgaag ccagaactcg aaatcaaaca tcagcaacgt gacacacaga
      481 cataagacgc ccgtctagtc gtggtctgtg gaacgctagc tccgctttgc caggagccgg
      541 agactttttc cgcatccaca atattacata tgtacatata tcgaagatag tgcgcgagtg
      601 agtgagggat ttgtgccgtg gatcccgatc cccttacata tatataaagg tagtgaaaag
      661 attttactca acattccaaa tagtgctttg tcaactggaa taccttttat tcaaatacgc
      721 agtgggccca tggatacttg tggattagta gcagaactgg cgcactatat cgacgcatat
      781 gctctgattg tttcccgcac taaatgagca gggattcggg cgaaaatgta ttttgaacgc
      841 aaacaagtgc gcaaaaaata ctagctccac cacgaaactg cacaaaacac cgccagaagc
      901 gagcagaacc tcgggccgca cgaccgagct tcgtaaagca acagaggatc ttaccaggag
      961 atagctcttc tccacataga ccaactgcca gggacaagct ccttgtcccc agccgacgct
     1021 aagtgaacgg aaaacggcca caaaacggcg actatcggct gccagaggat gaagcggcgc
     1081 tggtcgaaca acggcggctt catgcgccta ccggaggagt cgtcctcgga ggtcacgtcc
     1141 tcctcgaacg ggctcgtcct gccctcgggg gtgaacatgt cgccctcgtc gctggactcg
     1201 cacgactatt gcgatcagga cctttggctc tgcggcaacg agtccggttc gtttggcggc
     1261 tccaacggcc atggcctaag tcagcagcag cagagcgtca tcacgctggc catgcacggg
     1321 tgctccagca ctctgcccgc gcagacaacc atcattccga tcaacggcaa cgcgaatggg
     1381 aatggaggct ccaccaatgg ccaatatgtg ccgggtgcca ctaatctggg agcgttggcc
     1441 aacgggatgc tcaatggggg cttcaatgga atgcagcaac agattcagaa tggccacggc
     1501 ctcatcaact ccacaacgcc ctcaacgccg accaccccgc tccaccttca gcagaacctg
     1561 gggggcgcgg gcggcggcgg tatcggggga atgggtattc ttcaccacgc gaatggcacc
     1621 ccaaatggcc ttatcggagt tgtgggaggc ggcggcggag taggtcttgg agtaggcgga
     1681 ggcggagtgg gaggcctggg aatgcagcac acaccccgaa gcgattcggt gaattctata
     1741 tcttcaggtc gcgatgatct ctcgccttcg agcagcttga acggatactc ggcgaacgaa
     1801 agctgcgatg cgaagaagag caagaaggga cctgcgccac gggtgcaaga ggagctgtgc
     1861 ctggtttgcg gcgacagggc ctccggctac cactacaacg ccctcacctg tgagggctgc
     1921 aaggggttct ttcgacgcag cgttacgaag agcgccgtct actgctgcaa gttcgggcgc
     1981 gcctgcgaaa tggacatgta catgaggcga aagtgtcagg agtgccgcct gaaaaagtgc
     2041 ctggccgtgg gtatgcggcc ggaatgcgtc gtcccggaga accaatgtgc gatgaagcgg
     2101 cgcgaaaaga aggcccagaa ggagaaggac aaaatgacca cttcgccgag ctctcagcat
     2161 ggcggcaatg gcagcttggc ctctggtggc ggccaagact ttgttaagaa ggagattctt
     2221 gaccttatga catgcgagcc gccccagcat gccactattc cgctactacc tgatgaaata
     2281 ttggccaagt gtcaagcgcg caatatacct tccttaacgt acaatcagtt ggccgttata
     2341 tacaagttaa tttggtacca ggatggctat gagcagccat ctgaagagga tctcaggcgt
     2401 ataatgagtc aacccgatga gaacgagagc caaacggacg tcagctttcg gcatataacc
     2461 gagataacca tactcacggt ccagttgatt gttgagtttg ctaaaggtct accagcgttt
     2521 acaaagatac cccaggagga ccagatcacg ttactaaagg cctgctcgtc ggaggtgatg
     2581 atgctgcgta tggcacgacg ctatgaccac agctcggact caatattctt cgcgaataat
     2641 agatcatata cgcgggattc ttacaaaatg gccggaatgg ctgataacat tgaagacctg
     2701 ctgcatttct gccgccaaat gttctcgatg aaggtggaca acgtcgaata cgcgcttctc
     2761 actgccattg tgatcttctc ggaccggccg ggcctggaga aggcccaact agtcgaagcg
     2821 atccagagct actacatcga cacgctacgc atttatatac tcaaccgcca ctgcggcgac
     2881 tcaatgagcc tcgtcttcta cgcaaagctg ctctcgatcc tcaccgagct gcgtacgctg
     2941 ggcaaccaga acgccgagat gtgtttctca ctaaagctca aaaaccgcaa actgcccaag
     3001 ttcctcgagg agatctggga cgttcatgcc atcccgccat cggtccagtc gcaccttcag
     3061 attacccagg aggagaacga gcgtctcgag cgggctgagc gtatgcgggc atcggttggg
     3121 ggcgccatta ccgccggcat tgattgcgac tctgcctcca cttcggcggc ggcagccgcg
     3181 gcccagcatc agcctcagcc tcagccccag ccccaaccct cctccctgac ccagaacgat
     3241 tcccagcacc agacacagcc gcagctacaa cctcagctac cacctcagct gcaaggtcaa
     3301 ctgcaacccc agctccaacc acagcttcag acgcaactcc agccacagat tcaaccacag
     3361 ccacagctcc ttcccgtctc cgctcccgtg cccgcctccg taaccgcacc tggttccttg
     3421 tccgcggtca gtacgagcag cgaatacatg ggcggaagtg cggccatagg acccatcacg
     3481 ccggcaacca ccagcagtat cacggctgcc gttaccgcta gctccaccac atcagcggta
     3541 ccgatgggca acggagttgg agtcggtgtt ggggtgggcg gcaacgtcag catgtatgcg
     3601 aacgcccaga cggcgatggc cttgatgggt gtagccctgc attcgcacca agagcagctt
     3661 atcgggggag tggcggttaa gtcggagcac tcgacgactg catagcaggc gcagagtcag
     3721 ctccaccaac atcaccacca caacatcgac gtcctgctgg agtagaaagc gcagctgaac
     3781 ccacacagac ataggggaaa tggggaagtt ctctccagag agttcgagcc gaactaaata
     3841 gtaaaaagtg aataactaat ggacaagcgt aaaatgcagt tatttagtct taagcctgca
     3901 aatattacct attattcata caaattaaca tataatacag cctattaaca attacgctaa
     3961 agcttaattg aaaaagcttc aacaacaatt ggacaaacgc gttgaggaac cgggagaaaa
     4021 tttaagaaaa aaaaaaccat tgaaaattat gaaatttagt atacattttt tttgggtgga
     4081 tgtatgtcgc atcagactca cgatcaattc tcgaattttg ttaactaaat tgatcctcca
     4141 aactgcatgc gaaacagatc agaaaagaga acagacagta gggcgtgaac agagggaaga
     4201 gagaagagaa taaagattgt ttatatttaa aaaatatata aaataataat tactaactct
     4261 aaacgtaatg aaagcaactg tataatatct aactataact ataaattcgt actgtaggga
     4321 agtgagaaaa tctgttaaat gaaacaaaaa taatgataat aacattatca tccaccataa
     4381 ttaaaatcat ttaaagtaat taaaaacaaa acacttttaa aacacgcaaa acttggactg
     4441 attttataaa tattttttaa tcataaagaa aggcaacctg aaaaaaatat tacaaaaaca
     4501 aataacaaca tattttatta tgacaccctt atatgttttc aaaacgagaa tttaaattct
     4561 tagattctta taatttcatc caaaaatatt agccagcaaa aacctttatt attggcattg
     4621 tttttagaca tgttttcaaa aaaaactttg atattgaaac taaacaaagg ataatgaaat
     4681 gaaagtgatt ggagtcttac tcaaaaacca aaaggcatca aaaggtatta aattaaaaat
     4741 ataatctaat ttcgagttca agaaacactt tttggtggaa aatagttttc aatcactttg
     4801 ataaaaacca cacaaattaa taaatacatg catacaccaa aagacttcaa tatatatttt
     4861 taaaatttac attgataatt cgaaatttga ataagaatca catccatcta atttggctaa
     4921 atcaaaattt ttatgaaagc cacacaaaaa acgtgcaaat ttgtttactt tggcaatttt
     4981 tatgttatac aaaatttatg caattgattt tcaaaataat ttttattaga ttgtattagt
     5041 ttcattttgc tttgggatgt acattttaaa taaattttac tttaaattgt tggccttatt
     5101 ttaacttaaa tcaaatttat tctaatttta gtaaaaaaaa atgtgtttaa aattgaaaat
     5161 aagaacactg taaaatatta ataaaaaatt aaagtttaaa gtgattcttt tattatgtaa
     5221 aaagaagaca aaaaatatct tacgtagctt tctacttgaa ttgtgcaatt ttttactttt
     5281 actactaatc ctaatttaaa tataatttac acacacgcat acacacgcat acacacgcct
     5341 acacatacag ccacatattt ttaattttaa gtcaacctaa tttataaata tgaatttgta
     5401 taatgacgaa ctaaaattag catgacatca tggacatact tggaaataac tctatcaaac
     5461 gagctaaatg cattgaagaa gaaaattctt gttaaatata gtctgcactt cgacaaacga
     5521 aaatcagtga attc
//

SWALL:THBA_XENLA P18117 THYROID HORMONE RECEPTOR BETA-A. Length = 373 Score = 284 (105.0 bits), Expect = 9.2e-48, Sum P(2) = 9.2e-48 Identities = 50/105 (47%), Positives = 73/105 (69%) Query: 260 QEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSA--VYCCKFGRACEMDMYMRRKCQ 317 ++ELC+VCGD+A+GYHY +TCEGCKGFFRR++ K+ Y CK+ C +D R +CQ Sbjct: 15 KDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQ 74 Query: 318 ECRLKKCLAVGMRPECVVPENQCAMKRR---EKKAQKEKDKMTTS 359 ECR KKC+AVGM + V+ +N+ KR+ E + ++ KD++ S Sbjct: 75 ECRFKKCIAVGMATDLVLDDNKRLAKRKLIEENREKRRKDEIQKS 119 Score = 251 (93.4 bits), Expect = 9.2e-48, Sum P(2) = 9.2e-48 Identities = 71/227 (31%), Positives = 112/227 (49%) Query: 429 WYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIP 488 W Q P + I++ P+ + + +F T+I + +V+FAK LP F ++P Sbjct: 151 WKQKRKFLPEDIGQAPIVNAPEGGKVDLE-AFSQFTKIITPAITRVVDFAKKLPMFCELP 209 Query: 489 QEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFC 548 EDQI LLK C E+M LR A RYD S+++ + TR K G+ + + Sbjct: 210 CEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLG 269 Query: 549 RQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRHCGDSMS 607 + S +D+ E ALL A+++ S DRPGL + +E Q ++ YI R + Sbjct: 270 VSLSSFSLDDTEVALLQAVLLMSSDRPGLASVERIEKCQEGFLLAFEHYINYRKHNIAH- 328 Query: 608 LVFYAKLLSILTELRTLGNQNAEMCFSLKLK-NRKL--PKFLEEIWD 651 F+ KLL +T+LR +G +A +K++ +L P FLE D Sbjct: 329 --FWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 373

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